Rate-limiting steps for hepatic gluconeogenesis. Mechanism of oxamate inhibition of mitochondrial pyruvate metabolism.

@article{MartnRequero1986RatelimitingSF,
  title={Rate-limiting steps for hepatic gluconeogenesis. Mechanism of oxamate inhibition of mitochondrial pyruvate metabolism.},
  author={{\'A}ngeles Mart{\'i}n-Requero and Matilde S. Ayuso and Roberto Parrilla},
  journal={The Journal of biological chemistry},
  year={1986},
  volume={261 30},
  pages={13973-8}
}
Oxamate, structural analog of pyruvate, inhibits gluconeogenesis from pyruvate or substrates yielding pyruvate. The inhibitory effect is the result of a decreased mitochondrial pyruvate utilization. Although the inhibition of gluconeogenesis is competitive for pyruvate, in isolated mitochondria oxamate displays a mixed type kinetics inhibitory pattern of pyruvate utilization. Evidence is presented indicating that this mixed type pattern of inhibition is the result of the action of oxamate on… CONTINUE READING

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