Rate limiting factors in melanocortin 1 receptor signalling through the cAMP pathway.

@article{Ms2003RateLF,
  title={Rate limiting factors in melanocortin 1 receptor signalling through the cAMP pathway.},
  author={Jes{\'u}s S{\'a}nchez M{\'a}s and Ineke Gerritsen and Christa Hahmann and Celia Jim{\'e}nez-Cervantes and Jose Carlos Garcia-Borron},
  journal={Pigment cell research},
  year={2003},
  volume={16 5},
  pages={
          540-7
        }
}
The melanotropic actions of alpha-melanocyte-stimulating hormone (alpha-MSH) and other melanocortins are mediated by activation of the melanocortin 1 receptor (MC1R). This G protein-coupled receptor is positively coupled to Gs and triggers the cyclic adenosine mono-phosphate (cAMP) pathway. Mutations of the MC1R gene are associated with skin type and pigmentation phenotypes, and with increased risk of skin cancers. Genetic studies have demonstrated an heterozygote carrier effect for these… CONTINUE READING
BETA

Citations

Publications citing this paper.
SHOWING 1-10 OF 14 CITATIONS

Similar Papers

Loading similar papers…