Rate-dependent effects of diltiazem on human atrioventricular nodal properties.

@article{Talajic1992RatedependentEO,
  title={Rate-dependent effects of diltiazem on human atrioventricular nodal properties.},
  author={Mario R Talajic and Robert Lemery and Denis Roy and Christine Villemaire and Raymond Cartier and Benoit Coutu and Stanley Nattel},
  journal={Circulation},
  year={1992},
  volume={86 3},
  pages={870-7}
}
BACKGROUND Tachycardia enhances the channel-blocking effects of antiarrhythmic drugs. In contrast to the extensive data regarding the rate-dependent effects of sodium channel blockers in humans, little is known about the frequency-dependent effects of calcium channel blockers on human atrioventricular (AV) nodal properties. Accordingly, the purpose of this study was to evaluate the importance of heart rate in modulating the electrophysiological effects of diltiazem in humans. METHODS AND… CONTINUE READING