Rate constants and mechanisms of intrinsically disordered proteins binding to structured targets.

@article{Zhou2012RateCA,
  title={Rate constants and mechanisms of intrinsically disordered proteins binding to structured targets.},
  author={Huan-Xiang Zhou and Xiaodong Pang and Cai Lu},
  journal={Physical chemistry chemical physics : PCCP},
  year={2012},
  volume={14 30},
  pages={10466-76}
}
The binding of intrinsically disordered proteins (IDPs) to structured targets is gaining increasing attention. Here we review experimental and computational studies on the binding kinetics of IDPs. Experiments have yielded both the binding rate constants and the binding mechanisms, the latter via mutation and deletion studies and NMR techniques. Most computational studies have aimed at qualitative understanding of the binding rate constants or at mapping the free energy surfaces after the IDPs… CONTINUE READING