Rate and effects of spontaneous mutations that affect fitness in mutator Escherichia coli.

@article{Trindade2010RateAE,
  title={Rate and effects of spontaneous mutations that affect fitness in mutator Escherichia coli.},
  author={Sandra Trindade and L{\'i}lia Perfeito and Isabel Gordo},
  journal={Philosophical transactions of the Royal Society of London. Series B, Biological sciences},
  year={2010},
  volume={365 1544},
  pages={1177-86}
}
Knowledge of the mutational parameters that affect the evolution of organisms is of key importance in understanding the evolution of several characteristics of many natural populations, including recombination and mutation rates. In this study, we estimated the rate and mean effect of spontaneous mutations that affect fitness in a mutator strain of Escherichia coli and review some of the estimation methods associated with mutation accumulation (MA) experiments. We performed an MA experiment… CONTINUE READING

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