Rate- and Extent-Limiting Factors of Oral Drug Absorption: Theory and Applications.

@article{Sugano2015RateAE,
  title={Rate- and Extent-Limiting Factors of Oral Drug Absorption: Theory and Applications.},
  author={Kiyohiko Sugano and Katsuhide Terada},
  journal={Journal of pharmaceutical sciences},
  year={2015},
  volume={104 9},
  pages={2777-88}
}
The oral absorption of drugs has been represented by various concepts such as the absorption potential, the maximum absorbable dose, the biopharmaceutics classification system, and in vitro-in vivo correlation. The aim of this article is to provide an overview of the theoretical relationships between these concepts. It shows how a simple analytical solution for the fraction of a dose absorbed (Fa equation) can offer a theoretical base to tie together the various concepts, and discusses how this… CONTINUE READING
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