Rate Constant Determination for the Reaction of Hydroxyl and Glutathione Thiyl Radicals with Glutathione in Aqueous Solution

@inproceedings{Mezyk1996RateCD,
  title={Rate Constant Determination for the Reaction of Hydroxyl and Glutathione Thiyl Radicals with Glutathione in Aqueous Solution},
  author={Stephen P Mezyk},
  year={1996}
}
The techniques of pulse radiolysis, laser photolysis, and absorption spectroscopy have been used to investigate the glutathione disulfide radical anion formation over the pH range 7.0−13.0 in aqueous solution. Photolysis of the disulfide anion formed from the one-electron oxidation of reduced glutathione perturbs the disulfide anion/thiyl radical equilibrium, allowing the rate constant for thiyl radical reaction with glutathione to be uniquely determined from the transient absorption bleach and… CONTINUE READING