Ratchets and clocks: the cell cycle, ubiquitylation and protein turnover

  title={Ratchets and clocks: the cell cycle, ubiquitylation and protein turnover},
  author={S. I. Reed},
  journal={Nature Reviews Molecular Cell Biology},
Both the cell-cycle and ubiquitin-mediated-proteolysis fields have come of age over the past ten years. One byproduct of the impressive progress in these areas of investigation is the realization that they are intricately related: cell-cycle control is crucially dependent on the ubiquitin-mediated degradation of key regulatory proteins. Very recent advances have allowed an understanding of protein degradation and cell-cycle control at greatly enhanced levels of resolution. Consolidating these… CONTINUE READING

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