Ratchets and clocks: the cell cycle, ubiquitylation and protein turnover

@article{Reed2003RatchetsAC,
  title={Ratchets and clocks: the cell cycle, ubiquitylation and protein turnover},
  author={S. I. Reed},
  journal={Nature Reviews Molecular Cell Biology},
  year={2003},
  volume={4},
  pages={855-864}
}
Both the cell-cycle and ubiquitin-mediated-proteolysis fields have come of age over the past ten years. One byproduct of the impressive progress in these areas of investigation is the realization that they are intricately related: cell-cycle control is crucially dependent on the ubiquitin-mediated degradation of key regulatory proteins. Very recent advances have allowed an understanding of protein degradation and cell-cycle control at greatly enhanced levels of resolution. Consolidating these… CONTINUE READING

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Role of SCFSkp2 ubiquitin ligase in the degradation of p21Cip1 during S-phase

  • G Bornstein
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