Rat strain-dependent susceptibility to ischemia-induced retinopathy associated with retinal vascular endothelial growth factor regulation.

@article{Lu2007RatSS,
  title={Rat strain-dependent susceptibility to ischemia-induced retinopathy associated with retinal vascular endothelial growth factor regulation.},
  author={Kangmo Lu and Yuehua Zhou and Ken Kaufman and Robert A Mott and Jian-xing Ma},
  journal={Journal of molecular endocrinology},
  year={2007},
  volume={38 4},
  pages={423-32}
}
Vascular endothelial growth factor (VEGF) is a potent inflammation, vascular permeability, and angiogenic factor. Variations of the VEGF gene are implicated in the pathogenesis of diabetic retinopathy. Previous studies have shown that Brown Norway (BN) rats have higher retinal VEGF levels and more severe retinal vascular leakage than Sprague-Dawley (SD) rats in response to ischemia and diabetes. To investigate the molecular mechanism of vascular leakage in this animal model, F2 progeny were… CONTINUE READING
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