Rat-specific decreases in platelet count caused by a humanized monoclonal antibody against sclerostin.

@article{Rudmann2012RatspecificDI,
  title={Rat-specific decreases in platelet count caused by a humanized monoclonal antibody against sclerostin.},
  author={Daniel G Rudmann and Todd J Page and John L Vahle and Luc E. Chouinard and Solomon Haile and Florence Poitout and Gary B. Baskin and Andr{\'e}-Jean Lambert and Pamela Walker and Genevi{\`e}ve Glazier and Malaika Sharon Awori and Lise Bernier},
  journal={Toxicological sciences : an official journal of the Society of Toxicology},
  year={2012},
  volume={125 2},
  pages={586-94}
}
LY2541546 is a humanized monoclonal antibody (IgG(4)) that has been optimized for neutralizing activity against sclerostin. In 5-week and 6-month nonclinical safety studies in rats, LY2541546 caused dose-dependent reversible decreases in platelet counts accompanied by accelerated platelet production, increased megakaryocytes, and altered megakaryocyte morphology. These treatment-related effects resulted in altered primary hemostasis as manifested by prolonged bleeding after phlebotomy or… CONTINUE READING

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