Rat skeletal muscle mitochondrial [Ca2+] and injury from downhill walking.

  title={Rat skeletal muscle mitochondrial [Ca2+] and injury from downhill walking.},
  author={Chengyu Duan and Michael Delp and Deborah A. Hayes and P D Delp and Robert B Armstrong},
  journal={Journal of applied physiology},
  volume={68 3},
The purpose of this study was to evaluate the relationship between mitochondrial Ca2+ concentration (MCC) and the extent of muscle injury in rats that have performed prolonged downhill walking (eccentric exercise). MCC was used as an indicator of elevated [Ca2+] in the muscles, and injury was estimated from histochemical analysis of muscle cross sections by determining the numbers of intact fibers per unit area in the muscles. Elevations in MCC in the soleus and vastus intermedius muscles over… CONTINUE READING


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