Rat serum carboxylesterase. Cloning, expression, regulation, and evidence of secretion from liver.

@article{Yan1995RatSC,
  title={Rat serum carboxylesterase. Cloning, expression, regulation, and evidence of secretion from liver.},
  author={Ben Yan and Dongfang Yang and P Y Bullock and Andrew Parkinson},
  journal={The Journal of biological chemistry},
  year={1995},
  volume={270 32},
  pages={19128-34}
}
Multiple forms of carboxylesterase have been identified in rat liver, and five carboxylesterases (designated hydrolases A, B, C, S, and egasyn) have been cloned. Hydrolases A, B, C, and egasyn all have a C-terminal consensus sequence (HXEL) for retaining proteins in the endoplasmic reticulum, and these carboxylesterases are found in rat liver microsomes. In contrast, hydrolase S lacks this C-terminal consensus sequence and is presumed to be secreted. In order to test this hypothesis, a… CONTINUE READING

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