Rat self administration of ethanol: Enhancement by darkness and exogenous melatonin

@article{Smith1980RatSA,
  title={Rat self administration of ethanol: Enhancement by darkness and exogenous melatonin},
  author={Dorry Smith and Tian Po Oei and Kim. T. Ng and Shiro Patrick Armstrong},
  journal={Physiology & Behavior},
  year={1980},
  volume={25},
  pages={449-455}
}
Abstract Using an FT 60 schedule, rats on 100% free feeding tested in the dark phase of a 12:12 light-dark cycle were trained to self-administer ethanol intravenously. The effect was dose-dependent with 20% ethanol being the preferred dose as measured by the number of infusions. Daily administration of 1.5 mg/kg melatonin significantly increased ethanol self-injection in the dark but not in the light. The time of day of testing and/or drug administration may be an important variable in studies… CONTINUE READING
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