Rat retinal transcriptome: effects of aging and AMD-like retinopathy.

  title={Rat retinal transcriptome: effects of aging and AMD-like retinopathy.},
  author={Oyuna S. Kozhevnikova and Elena E Korbolina and Nikita I. Ershov and Natalia G. Kolosova},
  journal={Cell cycle},
  volume={12 11},
Pathogenesis of age-related macular degeneration (AMD), the leading cause of vision loss in the elderly, remains poorly understood due to the paucity of animal models that fully replicate the human disease. Recently, we showed that senescence-accelerated OXYS rats develop a retinopathy similar to human AMD. To identify alterations in response to normal aging and progression of AMD-like retinopathy, we compared gene expression profiles of retina from 3- and 18-mo-old OXYS and control Wistar rats… CONTINUE READING
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