Rat poorly predicts the combined non-absorbed and presystemically metabolized fractions in the human.

@article{Bueters2013RatPP,
  title={Rat poorly predicts the combined non-absorbed and presystemically metabolized fractions in the human.},
  author={Tjerk J H Bueters and Sanja Juric and Anna-Karin Sohlenius-Sternbeck and Yin Chang Hu and Johan Bylund},
  journal={Xenobiotica; the fate of foreign compounds in biological systems},
  year={2013},
  volume={43 7},
  pages={607-16}
}
1. Intestinal loss, 1 - (Fobs/fH), is the missing fraction of the dose that is unexplained by systemic clearance. Here, we investigated whether intestinal loss in rat is predictive for human, and whether intestinal metabolism explained observed differences between rat and human. 2. For 81 marketed drugs, human and rat intestinal loss values were calculated from the literature and in-house sources. To examine the contribution of intestinal cytochrome P450-mediated metabolism to the high observed… CONTINUE READING
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