Rat oligodendroglial cell lines express a functional receptor for the chemokine CCL3 (macrophage inflammatory protein-1alpha).

Regulation of migration, proliferation and differentiation of oligodendrocyte precursor cells is central for the accurate assembly of myelin in the CNS. The recent demonstration that oligodendrocyte precursors express chemokine receptors suggests that chemokines are candidates to play a role in the regulation of migration, since they are important molecules… CONTINUE READING