Rat nicotinic ACh receptor alpha7 and beta2 subunits co-assemble to form functional heteromeric nicotinic receptor channels.

@article{Khiroug2002RatNA,
  title={Rat nicotinic ACh receptor alpha7 and beta2 subunits co-assemble to form functional heteromeric nicotinic receptor channels.},
  author={Serguei S Khiroug and Patricia C Harkness and Patricia W. Lamb and Sterling N Sudweeks and Leonard S Khiroug and Neil S Millar and Jerrel L Yakel},
  journal={The Journal of physiology},
  year={2002},
  volume={540 Pt 2},
  pages={425-34}
}
Rat hippocampal interneurons express diverse subtypes of functional nicotinic acetylcholine receptors (nAChRs), including alpha7-containing receptors that have properties unlike those expected for homomeric alpha7 nAChRs. We previously reported a strong correlation between expression of the alpha7 and of the beta2 subunits in individual neurons. To explore whether co-assembly of the alpha7 and beta2 subunits might occur, these subunits were co-expressed in Xenopus oocytes and the functional… CONTINUE READING