Rat neuronal leucine-rich repeat protein-3: cloning and regulation of the gene expression.

@article{Fukamachi2001RatNL,
  title={Rat neuronal leucine-rich repeat protein-3: cloning and regulation of the gene expression.},
  author={Katsumi Fukamachi and Yoichiro Matsuoka and Chifumi Kitanaka and Yoshiyuki Kuchino and Hiroyuki Tsuda},
  journal={Biochemical and biophysical research communications},
  year={2001},
  volume={287 1},
  pages={257-63}
}
Rat neuronal leucine-rich repeat protein-3 (rNLRR-3) gene was isolated and cloned from fibrosarcoma cells overexpressing c-Ha-ras. Stable expression of constitutively active forms of Ras (H-Ras(V12) or v-H-Ras) led to a two- to fourfold increase in rNLRR-3 mRNA in rat normal fibroblasts (3Y1). When cells expressing H-Ras(V12) were treated with mitogen activated protein kinase (MAPK) kinase inhibitors (U0126, PD98059), suppression of rNLRR-3 mRNA correlated well with a reduction in MAPK activity… CONTINUE READING