Rat models of autosomal dominant polycystic kidney disease.

@article{Gretz1996RatMO,
  title={Rat models of autosomal dominant polycystic kidney disease.},
  author={Norbert Gretz and Bettina Kraenzlin and Roxana Pey and Gisela Schieren and Jiirgen Bach and Nicholas Obermueller and Isabella Ceccherini and Ingrid Kloeting and Peter Rohmeiss and Sebastian Bachmann and M. R. Hafner},
  journal={Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association},
  year={1996},
  volume={11 Suppl 6},
  pages={46-51}
}
Several rat models of polycystic kidney disease (PKD) have been published. The only rat model of autosomal dominant polycystic kidney disease currently used is the so-called Hannover rat (Han:SPRD cy/+). This model is characterized by a slow progression of uraemia, proteinuria and hyperlipidaemia. Histological changes clearly resemble those seen is human PKD. The localization of Na+/K(+)-ATPase correlating with the phenotype of the cysts--basal in moderately expanded and apical in highly… CONTINUE READING

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