Rat model of Parkinson's disease with bilateral motor abnormalities, reversible with levodopa, and dyskinesias.

@article{Paill2007RatMO,
  title={Rat model of Parkinson's disease with bilateral motor abnormalities, reversible with levodopa, and dyskinesias.},
  author={Vincent Paill{\'e} and Vincent Henry and Laurent Lescaudron and Philippe Brachet and Philippe Damier},
  journal={Movement disorders : official journal of the Movement Disorder Society},
  year={2007},
  volume={22 4},
  pages={533-9}
}
Parkinson's disease (PD) is characterized by the bilateral degeneration of the midbrain dopamine-containing neurons with the most severe lesion in the posterolateral part of the substantia nigra pars compacta (SNpc). In humans, such lesions lead to specific motor abnormalities (i.e., akinesia, rigidity, and tremor) that are greatly improved by levodopa… CONTINUE READING