Rat model of Parkinson's disease: Chronic central delivery of 1-methyl-4-phenylpyridinium (MPP<ce:sup loc=post>+</ce:sup>)

@article{Yazdani2006RatMO,
  title={Rat model of Parkinson's disease: Chronic central delivery of 1-methyl-4-phenylpyridinium (MPP<ce:sup loc=post>+</ce:sup>)},
  author={Umar Yazdani and Dwight C. German and Chen Liang and Lawrence Manzino and Gail D. Zeevalk},
  journal={Experimental Neurology},
  year={2006},
  volume={200},
  pages={172-183}
}
Mitochondrial dysfunction is observed in sporadic Parkinson's disease (PD) and may contribute to progressive neurodegeneration. While acute models of mitochondrial dysfunction have been used for many years to investigate PD, chronic models may better replicate the cellular disturbances caused by long-standing mitochondrial derangements and may represent a better model for neurotherapeutic testing. This study sought to develop a chronic model of PD that has the advantages of continuous low level… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 26 extracted citations

Similar Papers

Loading similar papers…