Rat mast cell protease I alters cell metabolism.

  title={Rat mast cell protease I alters cell metabolism.},
  author={I-J. Chan and Michael D. Tharp},
  journal={The Journal of investigative dermatology},
  volume={103 1},
Rat connective tissue mast cells are known to store significant amounts of mast cell protease I (RMCP I), which suppresses normal cell growth and mediates cytotoxicity against tumor cell lines, including the fibrosarcoma cell line FL. To better define its effects on FL cells, RMCP I was added to FL cultures for 30 min. Analysis of de novo nuclear protein synthesis revealed that RMCP I suppressed the expression of three proteins (41, 46, and 69 kD) and enhanced the expression of two other… CONTINUE READING