Rat liver microsomal glucose-6-P translocase. Effect of physiological status on inhibition and labeling by stilbene disulfonic acid derivatives.

@article{Zoccoli1982RatLM,
  title={Rat liver microsomal glucose-6-P translocase. Effect of physiological status on inhibition and labeling by stilbene disulfonic acid derivatives.},
  author={M A Zoccoli and Richard R Hoopes and Manfred L. Karnovsky},
  journal={The Journal of biological chemistry},
  year={1982},
  volume={257 19},
  pages={11296-300}
}
Intact microsomes from groups of fed, fasted, glucocorticoid-treated (triamcinolone) and diabetic (alloxan) rats were reacted with 4,4'-diisothiocyanostilbene-2,2'-disulfonic (DIDS), a specific inhibitor of microsomal glucose-6-P translocase. The concentrations that inhibit by 50% were 41 +/- 2, 31 +/- 1, 39 +/- 4, and 18 +/- 1 microM (mean +/- S.E.; n = 3); (order as above). The maximal levels of inhibition of the translocase by DIDS were 66 +/- 2, 79 +/- 2, 63 +/- 1, and 88 +/- 1… CONTINUE READING
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