Rat liver glutathione: possible role as a reservoir of cysteine.

  title={Rat liver glutathione: possible role as a reservoir of cysteine.},
  author={N. Tateishi and T. Higashi and A. Naruse and K. Nakashima and H. Shiozaki},
  journal={The Journal of nutrition},
  volume={107 1},
Rat liver contains a high concentration (7-8mM) of reduced glutathione and its level changes rapidly when starving or feeding rats. We concluded that one of the functions of liver glutathione was to act as a reservoir of cysteine. When starved rats were fed a protein-free diet, the increase in liver glutathione was dependent on the amount of cysteine added to the diet. A cysteine-dependent increase of glutathione was also observed in rats fed a diet containing gelatin with cysteine, but the… Expand
Turnover of Glutathione in Rat Liver
The glutathione content of rat liver is usually 7 to 8 μmol/g. After starving rats for one day, glutathione decreases to between two-thirds and half the normal level. When starved rats are fed a dietExpand
Ontogenic changes in hepatic glutathione and metallothionein in rats and the effect of a low-sulphur-containing diet.
The results suggest that even with a maternal nutritional deficiency of sulphur amino acids, the transfer of cysteine to the fetus is not impaired and the hepatic intra-organ degradation of glutathione is continued in these pups for a prolonged period after birth compared with pups born from control mothers. Expand
Effect of dietary protein deficiency and L-2-oxothiazolidine-4-carboxylate on the diurnal rhythm of hepatic glutathione in the rat.
It was concluded that in addition to cysteine availability, previous dietary protein status plays a key role in the regulation of the feeding-induced diurnal rhythm of hepatic GSH concentration in rats. Expand
Blood and Liver Concentrations of Glutathione, and Plasma Concentrations of Sulfur-Containing Amino Acids in Chicks Fed Deficient, Adequate, or Excess Levels of Dietary Cysteine
  • K. Boebel, D. Baker
  • Chemistry, Medicine
  • Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine
  • 1983
Abstract Experiments were conducted with young male chicks to examine the influence of cysteine status on blood and liver glutathione (GSH) concentrations and plasma sulfur amino acids. TheExpand
Hepatic cysteine dioxygenase activity and sulfur amino acid metabolism in rats: possible indicators in the evaluation of protein quality.
It is suggested that urinary taurine excretion and hepatic cysteine dioxygenase activity may be useful as sensitive indicators of the nutritional value of dietary protein. Expand
Glutathione content of the small intestine: regulation and function.
  • F. Kelly
  • Biology, Medicine
  • The British journal of nutrition
  • 1993
If glutathione plays a major role in the defence of the intestinal mucosa from ingested toxins then depletion of this defence during periods of food restriction could significantly increase the susceptibility of the individual to toxins present in the diet. Expand
Methionine metabolism in mammals: concentration of metabolites in rat tissues.
It is concluded that the maintenance of the concentration of methionine is the primary result of the various homeostatic mechanisms and most previous reports have overestimated the tissue content of adenosylhomocysteine. Expand
The Role of the Cystathionine Pathway in Glutathione Regulation by Isolated Hepatocytes
Freshly isolated hepatocytes were incubated in a complete medium including 10% fetal calf serum and [35S] amino acids. The rate of [35S] GSH synthesis paralleled the rate of uptake of [35S]Expand
Dietary l-cysteine inhibits d-galactosamine-induced acute liver injury in rats
The effects of l-cysteine (1 and 2%) on the antioxidative system were examined in rats with d-galactosamine (d-GalN)-induced injury. These rats showed increases in serum antioxidative enzyme andExpand
The Effect of Dietary Sulfur on: I. Glutathione S-Transferase Activity in Rat Lung and Liver; and II. The Hepatic Metabolism and Urinary Excretion of Acetaminophen in Adult Male Rats
The liver administration of APAP increased tissue glutathione (GSH) concentration but did not affect the activities of GSH S-T, sulfotransferase (ST), and UDP-glucuronyltransferase (UDP-GT). Expand