Rat liver carnitine palmitoyltransferase 1 forms an oligomeric complex within the outer mitochondrial membrane.

@article{Faye2007RatLC,
  title={Rat liver carnitine palmitoyltransferase 1 forms an oligomeric complex within the outer mitochondrial membrane.},
  author={Audrey Faye and Catherine Esnous and Nigel T. Price and Marie Anne Onfray and Jean Girard and Carina Prip-Buus},
  journal={The Journal of biological chemistry},
  year={2007},
  volume={282 37},
  pages={26908-16}
}
Carnitine palmitoyltransferase (CPT) 1A catalyzes the rate-limiting step in the transport of long chain acyl-CoAs from cytoplasm to the mitochondrial matrix by converting them to acylcarnitines. Located within the outer mitochondrial membrane, CPT1A activity is inhibited by malonyl-CoA, its allosteric inhibitor. In this study, we investigate for the first time the quaternary structure of rat CPT1A. Chemical cross-linking studies using intact mitochondria isolated from fed rat liver or from… CONTINUE READING
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