Rat lens aldose reductase inhibitory constituents of Nelumbo nucifera stamens

@article{Lim2006RatLA,
  title={Rat lens aldose reductase inhibitory constituents of Nelumbo nucifera stamens},
  author={Soon Sung Lim and Yu-Jung Jung and Sook Kyung Hyun and Yeon Sil Lee and Jae Sue Choi},
  journal={Phytotherapy Research},
  year={2006},
  volume={20}
}
Aldose reductase, the principal enzyme of the polyol pathway, has been shown to play an important role in the complications associated with diabetes. A methanol extract of the stamens of Nelumbo nucifera Gaertn. was shown to exert an inhibitory effect on rat lens aldose reductase (RLAR), and thus was fractionated using several organic solvents, including dichloromethane, ethyl acetate and n‐butanol. The ethyl acetate‐soluble fraction, which manifested potent RLAR‐inhibitory properties, was then… 
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