Rat intestinal precision-cut slices as an in vitro model to study xenobiotic interaction with transporters.

@article{Possidente2011RatIP,
  title={Rat intestinal precision-cut slices as an in vitro model to study xenobiotic interaction with transporters.},
  author={Mariapia Possidente and Stefania Dragoni and Giulia Franco and Maila Gori and Eugenio Bertelli and Elisabetta Teodori and Maria Frosini and Massimo Valoti},
  journal={European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V},
  year={2011},
  volume={79 2},
  pages={343-8}
}
ATP-binding cassette (ABC) proteins play key role in tissue defence by transporting metabolic waste and toxic chemicals out of the cells. Consequently, intact cell systems are required to study xenobiotic interactions with ATP-dependent transporters. The aim of the present study was to set up an intestinal precision-cut slice technique to study the interactions of ABC transporters with xenobiotics. Rat intestinal slices were incubated with verapamil, indomethacin and glibenclamide, and the… CONTINUE READING

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