Rat histidine decarboxylase promoter is regulated by gastrin through a protein kinase C pathway.

@article{Hoecker1996RatHD,
  title={Rat histidine decarboxylase promoter is regulated by gastrin through a protein kinase C pathway.},
  author={Michael Hoecker and Zhiping Zhang and David A Fenstermacher and Sven T{\aa}gerud and M Chulak and D Gladwin Joseph and Timothy C Wang},
  journal={The American journal of physiology},
  year={1996},
  volume={270 4 Pt 1},
  pages={G619-33}
}
The enzyme L-histidine decarboxylase (HDC; EC 4.1.1.22), which converts L-histidine to histamine, plays a key role in the regulation of acid secretion. In the rat and human stomach, the peptide hormone gastrin appears to be one of the main regulators of HDC expression. In rats, marked elevation of gastric HDC mRNA abundance was observed within 12 h after induction of hypergastrinemia by a single injection of the proton-pump blocker omeprazole. In situ hybridization revealed that HDC expression… CONTINUE READING