Rat hepatocytes and Kupffer cells interact to produce interleukin-8 (CINC) in the setting of ethanol.

@article{Maher1995RatHA,
  title={Rat hepatocytes and Kupffer cells interact to produce interleukin-8 (CINC) in the setting of ethanol.},
  author={Jacquelyn J. Maher},
  journal={The American journal of physiology},
  year={1995},
  volume={269 4 Pt 1},
  pages={G518-23}
}
Interleukin-8 is a neutrophil chemoattractant that has been implicated in the pathogenesis of alcoholic hepatitis. The mechanism of ethanol-induced interleukin-8 production in liver is uncertain, although hepatocytes and Kupffer cells have both been proposed as sources of the chemokine. In this study we investigated whether short-term ethanol exposure stimulates production of rat interleukin-8 [cytokine-induced neutrophil chemoattractant (CINC)] by normal rat hepatocytes and Kupffer cells in… CONTINUE READING