Rat hepatic coenzyme A is redistributed in response to mitochondrial acyl-coenzyme A accumulation.

@article{Brass1992RatHC,
  title={Rat hepatic coenzyme A is redistributed in response to mitochondrial acyl-coenzyme A accumulation.},
  author={Eric P. Brass and Larry J. Ruff},
  journal={The Journal of nutrition},
  year={1992},
  volume={122 11},
  pages={2094-100}
}
Coenzyme A without an acyl-thioester (CoASH) is required for numerous cellular reactions, and sequestration of CoASH as acyl-CoAs may impair metabolic function. Increased total CoA protects the cell from acyl-CoA accumulation, and enhanced CoA biosynthesis may represent a compensatory response in metabolic disease. To test the hypothesis that cellular CoA is redistributed from the cytosol to the mitochondria in response to mitochondrial acyl-CoA accretion, the subcellular distribution of… CONTINUE READING

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