Rat growth hormone gene expression. Both cell-specific and thyroid hormone response elements are required for thyroid hormone regulation.

@article{Ye1988RatGH,
  title={Rat growth hormone gene expression. Both cell-specific and thyroid hormone response elements are required for thyroid hormone regulation.},
  author={Zaiming Sam Ye and Barry Marc Forman and Agust{\'i}n Aranda and Alejandro Pascual and Hyo Young Park and Juan P{\'e}rez Casanova and Herbert H. Samuels},
  journal={The Journal of biological chemistry},
  year={1988},
  volume={263 16},
  pages={
          7821-9
        }
}
The elements involved in mediating cell-specific and thyroid hormone stimulation of rat growth hormone gene expression have been defined by transfection studies and by nuclease footprinting. 5'-Flanking DNA extending to -104 can mediate cell-specific expression, and this is enhanced 3- to 4-fold with DNA extending to -145. Cell-specific factors, found only in rat growth hormone producing cells, bind within the -137/-107 and -95/-65 regions, and competition studies suggest that the same factor… CONTINUE READING

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-9 of 9 citations