Rat glioblastoma cells expressing an antisense RNA to the insulin-like growth factor-1 (IGF-1) receptor are nontumorigenic and induce regression of wild-type tumors.

@article{Resnicoff1994RatGC,
  title={Rat glioblastoma cells expressing an antisense RNA to the insulin-like growth factor-1 (IGF-1) receptor are nontumorigenic and induce regression of wild-type tumors.},
  author={Mariana Resnicoff and Christian Sell and Michele Rubini and Domenico Coppola and Diane M Ambrose and Renato Baserga and Raphael Rubin},
  journal={Cancer research},
  year={1994},
  volume={54 8},
  pages={2218-22}
}
Insulin-like growth factor-1 (IGF-1) and IGF-2 are critical regulators of cell proliferation. The growth-promoting action of both ligands is mediated by the type 1 IGF receptor (IGF-1R). We have investigated the role of the IGF-1R in the growth and tumorigenicity of rat C6 glioblastoma cells. For this purpose, antisense RNA to IGF-1R RNA was introduced into cells by either the addition of oligodeoxynucleotides or by transfection with plasmids that express antisense RNA to IGF-1R RNA. At low… CONTINUE READING

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References

Publications referenced by this paper.
Showing 1-10 of 41 references

Growth regulation of human glioblastoma T 98 G cells by insulin like growth factor - i ( IGF - l ) and the IGF - 1 receptor

E. Craig, B. J. McCarthy, S. C. Wadsworth
J . Cell . Physiol . • 1994

Cell cycle and growth control.

Critical reviews in eukaryotic gene expression • 1993

Insulin - like growth factor - i and its receptor mediate the autocrine proliferation of human ovarian carcinoma cell lines

M. M. Rechler
Lab . Invest . • 1993

Insulin - like growth factor 1 ( IGF - 1 ) production by astroglial cells : regulation and importance for epidermal growth factor - induced cell replication

W. L. Lowe, T. Meyer, C. W. Karpen, L. R. Lorentzen
J . Neuro . Res . • 1993

The role of the IGF - 1 receptor in the stimulation of cells by short pulses of growth factors

M. Resnicoff, A Ambrose, D. Coppola, R. Rubin
1993

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