Rat eggs cannot wait: Spontaneous exit from meiotic metaphase-II arrest.

@article{Chebotareva2011RatEC,
  title={Rat eggs cannot wait: Spontaneous exit from meiotic metaphase-II arrest.},
  author={Tatiana Chebotareva and Jane Taylor and John J. Mullins and Ian Wilmut},
  journal={Molecular reproduction and development},
  year={2011},
  volume={78 10-11},
  pages={795-807}
}
Mammalian eggs await fertilisation while arrested at the second metaphase stage of meiotic division. A network of signalling pathways enables the establishment and maintenance of this metaphase-II arrest. In the absence of fertilisation, mammalian eggs can spontaneously exit metaphase II when parthenogenetically stimulated, or sometimes without any obvious stimulation. Ovulated rat eggs abortively release from metaphase-II arrest once removed from egg donors. Spontaneously activated rat eggs… CONTINUE READING

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