Rat brain serotonin receptors in Xenopus oocytes are coupled by intracellular calcium to endogenous channels.

@article{Takahashi1987RatBS,
  title={Rat brain serotonin receptors in Xenopus oocytes are coupled by intracellular calcium to endogenous channels.},
  author={Tsuyoshi Takahashi and Erwin Neher and Bert J. Sakmann},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1987},
  volume={84 14},
  pages={5063-7}
}
Serotonin activates chloride currents in Xenopus oocytes injected with a subfraction of rat brain poly(A)+ mRNA. Patch-clamp recordings from cell-attached patches showed that serotonin, applied locally outside the patch, caused the opening of channels of approximately equal to 3 pS conductance and an average lifetime of approximately equal to 100 msec. The extrapolated reversal potential indicated that the channels are chloride-selective. Single-channel currents with similar characteristics… CONTINUE READING

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