Rat bone marrow mesenchymal stem cells express glial markers and stimulate nerve regeneration.

@article{Tohill2004RatBM,
  title={Rat bone marrow mesenchymal stem cells express glial markers and stimulate nerve regeneration.},
  author={Mel P Tohill and Cristina M Mantovani and Mikael Wiberg and Giorgio Terenghi},
  journal={Neuroscience letters},
  year={2004},
  volume={362 3},
  pages={200-3}
}
Bone marrow mesenchymal stem cells can trans-differentiate into neuronal phenotypes. We examined the differentiation of marrow stromal cells (MSCs) in culture and during nerve regeneration. MSCs from adult rats were exposed to glial growth factor (GGF) to stimulate glial differentiation. Subsequently differentiated MSCs were retrovirally labelled with green fluorescent protein and transplanted into 1 cm nerve conduits in the rat sciatic nerve. Fifteen days post-operatively the conduits were… CONTINUE READING
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