Rat aortic smooth muscle cells in culture express kallikrein, kininogen, and bradykininase activity.

Abstract

We have studied rat vascular smooth muscle (VSM) cells in culture for the presence of key elements of the glandular kallikrein-kinin system. Direct radioimmunoassay (RIA) using antiserum against rat urinary kallikrein detected a glandular kallikrein-like enzyme (GKLE) in VSM cells and in media. VSM homogenates and culture media had kininogenase activity… (More)

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@article{Oza1990RatAS, title={Rat aortic smooth muscle cells in culture express kallikrein, kininogen, and bradykininase activity.}, author={Nirima Oza and Joel H Schwartz and Hanumanth Goud and Norman G. Levinsky}, journal={The Journal of clinical investigation}, year={1990}, volume={85 2}, pages={597-600} }