Rat Urinary Osteopontin and Neutrophil Gelatinase-Associated Lipocalin Improve Certainty of Detecting Drug-Induced Kidney Injury.

@article{Phillips2016RatUO,
  title={Rat Urinary Osteopontin and Neutrophil Gelatinase-Associated Lipocalin Improve Certainty of Detecting Drug-Induced Kidney Injury.},
  author={Jonathan Phillips and Daniel J. Holder and Daniela Ennulat and J Gautier and J. Sauer and Yi Yang and Eric McDuffie and Manisha Sonee and Y Gu and Sean P Troth and Karen M Lynch and Diane M Hamlin and David G. Peters and Dominique Brees and Elizabeth Gribble Walker},
  journal={Toxicological sciences : an official journal of the Society of Toxicology},
  year={2016},
  volume={151 2},
  pages={214-23}
}
Traditional kidney biomarkers are insensitive indicators of acute kidney injury, with meaningful changes occurring late in the course of injury. The aim of this work was to demonstrate the diagnostic potential of urinary osteopontin (OPN) and neutrophil gelatinase-associated lipocalin (NGAL) for drug-induced kidney injury (DIKI) in rats using data from a… CONTINUE READING