Rat Models of Human Type 1 Diabetes.

@article{Lenzen2020RatMO,
  title={Rat Models of Human Type 1 Diabetes.},
  author={Sigurd Lenzen and Tanja Arndt and Matthias Elsner and Dirk Wedekind and Anne J{\"o}rns},
  journal={Methods in molecular biology},
  year={2020},
  volume={2128},
  pages={
          69-85
        }
}
Rat models of human type 1 diabetes have been shown to be of great importance for the elucidation of the mechanisms underlying the development of autoimmune diabetes. The three major well-established spontaneous rat models are the BioBreeding (BB) diabetes-prone rat, the Komeda diabetes-prone (KDP) rat, and the IDDM (LEW.1AR1-iddm) rat. Their distinctive features are described with special reference to their pathology, immunology, and genetics and compared with the situation in patients with… 
5 Citations
Sphingolipids in Type 1 Diabetes: Focus on Beta-Cells
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The up-to-date status on the findings about sphingolipids in T1DM will be provided, the under-investigated research areas will be identified and perspectives for future studies will be given.
Remission of autoimmune diabetes by anti-TCR combination therapies with anti-IL-17A or/and anti-IL-6 in the IDDM rat model of type 1 diabetes
TLDR
Two therapies were initiated immediately after disease manifestation to reverse the diabetic metabolic state in the LEW resulting in sustained normoglycaemia with normalized serum C-peptide concentrations and the triple combination therapy achieved both goals in a complimentary anti-autoimmune and anti-inflammatory action.
Translation of curative therapy concepts with T cell and cytokine antibody combinations for type 1 diabetes reversal in the IDDM rat
TLDR
The double antibody combination of anti-TCR with anti-TNF-α proved to be the most suited therapy for reversal of the T1D metabolic state due to effective beta cell regeneration in an infiltration free pancreas.

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