Rat CNS white matter, but not gray matter, is nonpermissive for neuronal cell adhesion and fiber outgrowth.

@article{Savio1989RatCW,
  title={Rat CNS white matter, but not gray matter, is nonpermissive for neuronal cell adhesion and fiber outgrowth.},
  author={Tiziana Savio and Martin E. Schwab},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={1989},
  volume={9 4},
  pages={1126-33}
}
In adult mammalian CNS, axons mostly fail to regenerate after injury, while in the PNS they often succeed in reaching their previous targets. Crucial differences are present in the local tissue microenvironment of CNS and PNS. To investigate the substrate properties of nervous tissue for neuronal adhesion and fiber growth, we used frozen sections of rat CNS and PNS as culture substrates for neuroblastoma cells and for sympathetic and dorsal root ganglia. The results showed that CNS white matter… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 57 extracted citations

White matter of the CNS supports or inhibits neurite outgrowth in vitro depending on geometry.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 1999
View 11 Excerpts
Highly Influenced

References

Publications referenced by this paper.
Showing 1-10 of 25 references

An in vitro neuritepromoting antigen functions in axonal regeneration in vivo

W. D. Matthew
Science • 1987

Altered expression of neuronal cell adhesion molecules induced by nerve injury and repair

J. K. Daniloff, M. Grumet, F. Rieger, G. M. Edelman
J . Cell Biol . • 1986

Laminin and optic nerve regeneration in the goldfish.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 1985

Similar Papers

Loading similar papers…