Rasputin, the Drosophila homologue of the RasGAP SH3 binding protein, functions in ras- and Rho-mediated signaling.

@article{Pzmn2000RasputinTD,
  title={Rasputin, the Drosophila homologue of the RasGAP SH3 binding protein, functions in ras- and Rho-mediated signaling.},
  author={Cecilia P{\'a}zm{\'a}n and Caryl A. Mayes and Manolis Fanto and S. R. Haynes and Marek Mlodzik},
  journal={Development},
  year={2000},
  volume={127 8},
  pages={
          1715-25
        }
}
The small GTPase Ras plays an important role in many cellular signaling processes. Ras activity is negatively regulated by GTPase activating proteins (GAPs). It has been proposed that RasGAP may also function as an effector of Ras activity. We have identified and characterized the Drosophila homologue of the RasGAP-binding protein G3BP encoded by rasputin (rin). rin mutants are viable and display defects in photoreceptor recruitment and ommatidial polarity in the eye. Mutations in rin/G3BP… CONTINUE READING

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