Rasburicase improves hyperuricemia in patients with acute kidney injury secondary to rhabdomyolysis caused by ecstasy intoxication and exertional heat stroke

@article{Lin2011RasburicaseIH,
  title={Rasburicase improves hyperuricemia in patients with acute kidney injury secondary to rhabdomyolysis caused by ecstasy intoxication and exertional heat stroke},
  author={Pei-Yi Lin and Chun-Chen Lin and Hsi-Che Liu and Ming-Dar Lee and Hung-Chang Lee and Che-Sheng Ho and Nan-Chang Chiu and Chun-Chih Peng and Fu-yuan Huang and J D Tsai},
  journal={Pediatric Critical Care Medicine},
  year={2011},
  volume={12},
  pages={e424-e427}
}
Objective: To report the successful use of rasburicase in two children with hyperuricemia secondary to severe rhabdomyolysis. Design: Case report. Setting: Pediatric intensive care unit in a freestanding quaternary hospital. Patients: Two pediatric patients with severe rhabdomyolysis and hyperuricemia caused by ecstasy intoxication and exertional heat stroke. Intervention: Use of a single low dose (6 mg) of rasburicase, a urate oxidase enzyme. Measurements and Main Results: Rasburicase was… 

Rasburicase for hyperuricemia in hemolytic uremic syndrome

It is postulate that aggressive management of the high serum UA level with rasburicase and fluid hydration accelerated the recovery of the patient and further studies are needed to determine the role of rasBuricase in the treatment of hyperuricemia in patients with HUS.

Reversal of Severe Volume Deplete Acute Kidney Injury by Rasburicase

It is believed that rasburicase crossed the glomerular filtration barrier and entered the tubular fluid where it dissolved intra-tubular uric acid, thus relieving obstruction and rapidly enhancing urine excretion and improving renal function.

An Unusual Mimicker of Tumor Lysis Syndrome with Hepatic and Renal Failure

A 52-year-old male presented to the emergency department with a 3-day history of malaise, nausea, and pruritic rash. He had a history of treated hepatitis C, primary immune thrombocytopenic purpura

Heat stroke with bimodal rhabdomyolysis: a case report and review of the literature

Physicians should pay special attention to the stress of rehabilitation exercises, which may cause collapsed muscles that are injured by severe heat stroke to repeatedly flare up.

Allopurinol attenuates rhabdomyolysis-associated acute kidney injury: Renal and muscular protection.

Rasburicase for acute kidney injury

The effect of rasburicase in AKI needs to be studied and a significant reduction of SUA along with improvement in renal parameters is resulted in.

Hyperuricemia and Progression of Chronic Kidney Disease: A Review from Physiology and Pathogenesis to the Role of Urate-Lowering Therapy

In this comprehensive review, the source and physiology of UA are introduced, the mechanisms that explain the reciprocal relationship between hyperuricemia and kidney disease are reviewed, and current evidence supporting the use of ULT to postpone renal disease progression in patients with hyperuricaemia and gout is summarized.

Electrolyte Disorders, Acute Kidney Injury and Rhabdomyolysis

Drowning may also cause cerebral (hypoxic brain injury), cardiac (atrial fibrillation) and haematologic complications (disseminated intravascular coagulation (DIC), haemolysis) as well as multi-organ failure [8].

Ecstasy induces reactive oxygen species, kidney water absorption and rhabdomyolysis in normal rats. Effect of N-acetylcysteine and Allopurinol in oxidative stress and muscle fiber damage

Experiments showed that Ec induced an increase in AQP2 expression, evidencing another mechanism that might contribute to cause rapid hyponatremia.

Recurrent acute kidney injury following bath salts intoxication.

A case of recurrent acute kidney injury associated with repeated bath salts intoxication is reported, who presented with neurologic and cardiovascular symptoms and signs and developed rhabdomyolysis, hyperuricemia, and metabolic acidosis as part of the clinical presentation.

References

SHOWING 1-10 OF 26 REFERENCES

Rasburicase improves hyperuricemia in infants with acute kidney injury

A single intravenously administered bolus of rasburicase appears to be a novel treatment for hyperuricemia in infants with AKI, and all patients demonstrated a normalization of uric acid level without need of renal replacement therapy.

Efficacy of rasburicase in hyperuricemia secondary to Lesch-Nyhan syndrome.

In summary, rasburicase proved to be a safe and effective treatment in a patient with Lesch-Nyhan syndrome with uric acid nephropathy in the neonatal period.

Single‐Dose Rasburicase 6 mg in the Management of Tumor Lysis Syndrome in Adults

In these 10 patients, uric acid concentrations remained low despite subsequent chemotherapy, and none required additional rasburicase doses, and warrant further investigation of a single 6‐mg dose of rasBuricase in adults with TLS or at high‐risk for developing TLS.

Control of plasma uric acid in adults at risk for tumor Lysis syndrome: efficacy and safety of rasburicase alone and rasburicase followed by allopurinol compared with allopurinol alone--results of a multicenter phase III study.

In adults with hyperuricemia or at high risk for TLS, rasburicase provided control of plasma uric acid more rapidly than allopurinol.

Hyperuricemic nephropathies.

Chronic asymptomatic hyperuricemia may predict the adverse cardiovascular consequences of insulin resistance, and may serve as an indicator of renal vascular disease or insulin resistance.

Efficacy and safety of rasburicase, a recombinant urate oxidase (Elitek™), in the management of malignancy-associated hyperuricemia in pediatric and adult patients: final results of a multicenter compassionate use trial

These data confirm that rasburicase is effective and safe for the treatment and prophylaxis of children and adults with malignancy-associated hyperuricemia.

Could uric acid have a role in acute renal failure?

The hypothesis is presented that hyperuricemia, particularly if chronic and marked, likely represents a true risk factor for ARF and may account for the paradoxic lack of benefit of diuretics in the management of ARF.

Rhabdomyolysis and acute kidney injury.

This review summarizes current views on the pathogenesis of myoglobin-induced kidney injury as well as on its prevention and treatment.

Uric Acid: A Novel Risk Factor for Acute Kidney Injury in High-Risk Cardiac Surgery Patients?

This preliminary study suggests that uric acid may be a novel risk factor for acute kidney injury in patients undergoing high-risk cardiovascular surgery.