RasGRP3 regulates the migration of glioma cells via interaction with Arp3

@inproceedings{Lee2015RasGRP3RT,
  title={RasGRP3 regulates the migration of glioma cells via interaction with Arp3},
  author={Hae Kyung Lee and Susan A Finniss and Simona Cazacu and Cunli Xiang and Laila M. Poisson and Peter M. Blumberg and Chaya Brodie},
  booktitle={Oncotarget},
  year={2015}
}
Glioblastoma (GBM), the most aggressive primary brain tumors, are highly infiltrative. Although GBM express high Ras activity and Ras proteins have been implicated in gliomagenesis, Ras-activating mutations are not frequent in these tumors. RasGRP3, an important signaling protein responsive to diacylglycerol (DAG), increases Ras activation. Here, we… CONTINUE READING