RasGRP1 overexpression in T-ALL increases basal nucleotide exchange on Ras rendering the Ras/PI3K/Akt pathway responsive to protumorigenic cytokines

@article{Ksionda2016RasGRP1OI,
  title={RasGRP1 overexpression in T-ALL increases basal nucleotide exchange on Ras rendering the Ras/PI3K/Akt pathway responsive to protumorigenic cytokines},
  author={Olga Ksionda and Alexis A Melton and Jens Bache and Milou Tenhagen and Jeroen Bakker and Ron{\'e}e Harvey and Stuart S. Winter and Ignacio Rubio and Jeroen P Roose},
  journal={Oncogene},
  year={2016},
  volume={35},
  pages={3658-3668}
}
Ras GTPases are activated by RasGEFs and inactivated by RasGAPs, which stimulate the hydrolysis of RasGTP to inactive RasGDP. GTPase-impairing somatic mutations in RAS genes, such as KRASG12D, are among the most common oncogenic events in metastatic cancer. A different type of cancer Ras signal, driven by overexpression of the RasGEF RasGRP1 (Ras guanine nucleotide-releasing protein 1), was recently implicated in pediatric T-cell acute lymphoblastic leukemia (T-ALL) patients and murine models… CONTINUE READING
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