RasGAP mediates neuronal survival in Drosophila through direct regulation of Rab5-dependent endocytosis.

@article{Rowshanravan2014RasGAPMN,
  title={RasGAP mediates neuronal survival in Drosophila through direct regulation of Rab5-dependent endocytosis.},
  author={Behzad Rowshanravan and Simon A. Woodcock and Jos{\'e} A. Botella and Claudia Kiermayer and Stephan Schneuwly and David A. Hughes},
  journal={Journal of cell science},
  year={2014},
  volume={127 Pt 13},
  pages={2849-61}
}
The GTPase Ras can either promote or inhibit cell survival. Inactivating mutations in Drosophila RasGAP (encoded by vap), a Ras GTPase-activating protein, lead to age-related brain degeneration. Genetic interactions implicate the epidermal growth factor receptor (EGFR)-Ras pathway in promoting neurodegeneration but the mechanism is not known. Here, we show that the Src homology 2 (SH2) domains of RasGAP are essential for its neuroprotective function. By using affinity purification and mass… CONTINUE READING