Ras uses the novel tumor suppressor RASSF1 as an effector to mediate apoptosis.

@article{Vos2000RasUT,
  title={Ras uses the novel tumor suppressor RASSF1 as an effector to mediate apoptosis.},
  author={Michele D. Vos and Chad A. Ellis and Andrea Bell and Michael J. Birrer and Geoffrey J. Clark},
  journal={The Journal of biological chemistry},
  year={2000},
  volume={275 46},
  pages={35669-72}
}
Although activated Ras proteins are usually associated with driving growth and transformation, they may also induce senescence, apoptosis, and terminal differentiation. The subversion of these anti-neoplastic effects during Ras-dependent tumor development may be as important as the acquisition of the pro-neoplastic effects. None of the currently identified potential Ras effector proteins can satisfactorily explain the apoptotic action of Ras. Consequently, we have sought to identify novel Ras… CONTINUE READING

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