Ras trafficking, localization and compartmentalized signalling.

  title={Ras trafficking, localization and compartmentalized signalling.},
  author={Ian A Prior and John F Hancock},
  journal={Seminars in cell & developmental biology},
  volume={23 2},
Ras proteins are proto-oncogenes that are frequently mutated in human cancers. Three closely related isoforms, HRAS, KRAS and NRAS, are expressed in all cells and have overlapping but distinctive functions. Recent work has revealed how differences between the Ras isoforms in their trafficking, localization and protein-membrane orientation enable signalling specificity to be determined. We review the various strategies used to characterize compartmentalized Ras localization and signalling… CONTINUE READING