Ras-specific exchange factor GRF: oligomerization through its Dbl homology domain and calcium-dependent activation of Raf.

@article{Anborgh1999RasspecificEF,
  title={Ras-specific exchange factor GRF: oligomerization through its Dbl homology domain and calcium-dependent activation of Raf.},
  author={Pieter H. Anborgh and Xiaozhong Qian and Alex G. Papageorge and William C. Vass and Jeffrey E Declue and Douglas R Lowy},
  journal={Molecular and cellular biology},
  year={1999},
  volume={19 7},
  pages={4611-22}
}
The full-length versions of the Ras-specific exchange factors Ras-GRF1 (GRF1) and Ras-GRF2 (GRF2), which are expressed in brain and a restricted number of other organs, possess an ionomycin-dependent activation of Erk mitogen-activated protein kinase activity in 293T cells (C. L. Farnsworth et al., Nature 376:524-527, 1995; N. P. Fam et al., Mol. Cell. Biol. 17:1396-1406, 1996). Each GRF protein contains a Dbl homology (DH) domain. A yeast two-hybrid screen was used to identify polypeptides… CONTINUE READING

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