Ras signaling is required for serum-induced hyphal differentiation in Candida albicans.

@article{Feng1999RasSI,
  title={Ras signaling is required for serum-induced hyphal differentiation in Candida albicans.},
  author={Qi Feng and Eric Summers and Baoqing Guo and Gerald Fink},
  journal={Journal of bacteriology},
  year={1999},
  volume={181 20},
  pages={6339-46}
}
Serum induces Candida albicans to make a rapid morphological change from the yeast cell form to hyphae. Contrary to the previous reports, we found that serum albumin does not play a critical role in this morphological change. Instead, a filtrate (molecular mass, <1 kDa) devoid of serum albumin induces hyphae. To study genes controlling this response, we have isolated the RAS1 gene from C. albicans by complementation. The Candida Ras1 protein, like Ras1 and Ras2 of Saccharomyces cerevisiae, has… CONTINUE READING