Ras signaling directs endothelial specification of VEGFR2+ vascular progenitor cells

  title={Ras signaling directs endothelial specification of VEGFR2+ vascular progenitor cells},
  author={Kyoko Kawasaki and Tetsuro Watabe and Hitoshi Sase and Masanori Hirashima and Hiroshi B. Koide and Yasuyuki Morishita and Keiko Yuki and Toshikuni Sasaoka and Toshio Suda and Motoya Katsuki and Kohei Miyazono and Keiji Miyazawa},
  journal={The Journal of Cell Biology},
  pages={131 - 141}
Vascular endothelial growth factor receptor 2 (VEGFR2) transmits signals of crucial importance to vasculogenesis, including proliferation, migration, and differentiation of vascular progenitor cells. Embryonic stem cell-derived VEGFR2(+) mesodermal cells differentiate into mural lineage in the presence of platelet derived growth factor (PDGF)-BB or serum but into endothelial lineage in response to VEGF-A. We found that inhibition of H-Ras function by a farnesyltransferase inhibitor or a… CONTINUE READING


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