Ras-related signaling pathways in valve development: ebb and flow.

@article{Yutzey2005RasrelatedSP,
  title={Ras-related signaling pathways in valve development: ebb and flow.},
  author={Katherine E. Yutzey and Melissa Colbert and Jeffrey Robbins},
  journal={Physiology},
  year={2005},
  volume={20},
  pages={390-7}
}
Congenital heart defects affect approximately 1 in every 100 live births, and deficits in the formation of the mitral, tricuspid, and outflow tract valves account for 20-25% of all cardiac malformations. Mutations in genes that affect Ras signaling have been identified in individuals with congenital valve disease associated with Noonan syndrome and neurofibromatosis type 1. Dissection of Ras-related signaling pathways during valvulogenesis provides seminal insight into cellular and molecular… CONTINUE READING

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